| 11/7/2020 | Arizona State (3-1,3-1) | 27 | at | Southern California | 21 | |||
| 11/14/2020 | Southern California | 34 | at | Arizona (0-5,0-5) | 30 | |||
| 11/21/2020 | Southern California | 33 | at | Utah (3-2,3-2) | 17 | |||
| 11/28/2020 | Colorado (4-2,3-1) | at | Southern California | CCD | ||||
| 12/6/2020 | Washington State (1-3,1-3) | 13 | at | Southern California | 38 | |||
| 12/12/2020 | Southern California | 43 | at | UCLA (3-4,3-4) | 38 | |||
| 12/18/2020 | Oregon (4-3,4-2) | 31 | at | Southern California | 24 | P12 Championship |
| vs Southern California | vs Other Opponents | Southern California compared to OOs | |
| Record: | 2-4 | 16-16 | |
| Points Scored: | 26.00 | 30.91 | 4.91 |
| Points Allowed: | 32.17 | 30.59 | 1.58 |
| Margin: | -6.17 | 0.32 | 6.49 |
| Total Points: | 58.17 | 61.50 | -3.33 |