| 9/7/2019 | Guilford | 43 | at | Huntingdon AL (8-4) | 69 | at USASC | ||
| 9/14/2019 | Guilford | 19 | at | Methodist (4-6) | 14 | at USASC | ||
| 9/21/2019 | Guilford | 14 | at | Washington and Lee (6-4,5-3) | 52 | |||
| 9/28/2019 | Shenandoah (6-4,4-4) | 26 | at | Guilford | 7 | |||
| 10/5/2019 | Randolph-Macon (9-2,7-1) | 34 | at | Guilford | 21 | |||
| 10/12/2019 | Guilford | 23 | at | Ferrum (4-6,3-5) | 45 | |||
| 10/26/2019 | Hampden-Sydney (1-9,0-8) | 27 | at | Guilford | 37 | |||
| 11/2/2019 | Guilford | 17 | at | Southern Virginia (4-6,2-6) | 30 | |||
| 11/9/2019 | Emory & Henry (7-3,6-2) | 38 | at | Guilford | 22 | |||
| 11/16/2019 | Guilford | 7 | at | Bridgewater VA (10-1,8-0) | 41 |
| vs Guilford | vs Other Opponents | Guilford compared to OOs | |
| Record: | 8-2 | 51-43 | |
| Points Scored: | 37.60 | 29.14 | -8.46 |
| Points Allowed: | 21.00 | 27.32 | -6.32 |
| Margin: | 16.60 | 1.82 | -14.78 |
| Total Points: | 58.60 | 56.46 | 2.14 |