| 9/7/2019 | Colorado State-Pueblo | 36 | at | Dixie State (8-3,7-3) | 7 | | | |
| 9/14/2019 | Colorado State-Pueblo | 42 | at | Chadron State (6-5,5-5) | 21 | | | |
| 9/21/2019 | Colorado Mines (12-1,10-0) | 34 | at | Colorado State-Pueblo | 14 | | | |
| 9/28/2019 | Texas A&M-Commerce (10-3) | 17 | at | Colorado State-Pueblo | 24 | | | LSC |
| 10/5/2019 | Colorado State-Pueblo | 21 | at | South Dakota Tech (3-8,2-8) | 13 | | | |
| 10/12/2019 | Colorado State-Pueblo | 31 | at | New Mexico Highlands (2-7,2-7) | 14 | | | |
| 10/19/2019 | Colorado Mesa (6-5,6-4) | 22 | at | Colorado State-Pueblo | 48 | | | |
| 10/26/2019 | Adams State (4-7,4-6) | 12 | at | Colorado State-Pueblo | 52 | | | |
| 11/2/2019 | Colorado State-Pueblo | 21 | at | Fort Lewis (2-7,2-7) | 13 | | | |
| 11/9/2019 | Black Hills State (3-8,2-8) | 0 | at | Colorado State-Pueblo | 58 | | | |
| 11/16/2019 | Western Colorado (5-6,5-5) | 7 | at | Colorado State-Pueblo | 34 | | | |
| 11/23/2019 | Augustana SD (9-3) | 0 | at | Colorado State-Pueblo | 17 | | | NSIC |
| 11/30/2019 | Colorado State-Pueblo | 7 | at | Minnesota State-Mankato (14-1) | 35 | | D2 Playoff Round 2 | at NSIC |