| 9/8/2018 | Central IA (8-2) | 16 | at | DePauw | 10 | IIAC | ||
| 9/15/2018 | Hiram (2-8,1-8) | 7 | at | DePauw | 45 | |||
| 9/22/2018 | DePauw | 21 | at | Wooster (5-5,4-5) | 24 | |||
| 9/29/2018 | Ohio Wesleyan (4-6,4-5) | 17 | at | DePauw | 38 | |||
| 10/6/2018 | DePauw | 28 | at | Oberlin (2-8,2-7) | 26 | |||
| 10/13/2018 | Denison (8-3,8-1) | 20 | at | DePauw | 12 | |||
| 10/20/2018 | DePauw | 23 | at | Wittenberg (9-1,8-1) | 38 | |||
| 10/27/2018 | DePauw | 19 | at | Allegheny (6-4,6-3) | 20 | |||
| 11/3/2018 | Kenyon (0-10,0-9) | 6 | at | DePauw | 38 | |||
| 11/10/2018 | DePauw | 17 | at | Wabash (9-1,8-1) | 24 |
| vs DePauw | vs Other Opponents | DePauw compared to OOs | |
| Record: | 6-4 | 47-44 | |
| Points Scored: | 19.80 | 28.36 | 8.56 |
| Points Allowed: | 25.10 | 27.88 | -2.78 |
| Margin: | -5.30 | 0.48 | 5.78 |
| Total Points: | 44.90 | 56.24 | -11.34 |