| 8/30/2018 | West Virginia State | 31 | at | Charleston WV (6-5,6-4) | 35 | | | |
| 9/8/2018 | Virginia-Wise (4-6,4-6) | 12 | at | West Virginia State | 33 | | | |
| 9/15/2018 | West Virginia State | 31 | at | Notre Dame OH (13-1,10-0) | 33 | | | |
| 9/22/2018 | Shepherd (7-3,7-3) | 27 | at | West Virginia State | 7 | | | |
| 9/29/2018 | West Virginia State | 31 | at | Glenville State (5-6,5-5) | 17 | | | |
| 10/6/2018 | Kentucky State (0-10) | 42 | at | West Virginia State | 61 | | | SIAC |
| 10/13/2018 | Concord (2-9,2-8) | 24 | at | West Virginia State | 52 | | | |
| 10/20/2018 | West Virginia State | 24 | at | West Liberty (3-8,3-7) | 36 | | | |
| 10/27/2018 | Fairmont State (9-2,8-2) | 41 | at | West Virginia State | 12 | | | |
| 11/3/2018 | West Virginia State | 31 | at | Urbana (5-6,4-6) | 28 | | | |
| 11/10/2018 | West Virginia Wesleyan (1-10,1-9) | 25 | at | West Virginia State | 45 | | | |