| 9/1/2018 | Adams State (4-7,4-6) | 7 | at | Colorado Mines | 49 | | | |
| 9/8/2018 | Colorado Mines | 42 | at | Black Hills State (3-8,2-8) | 20 | | | |
| 9/15/2018 | Colorado State-Pueblo (11-2,10-1) | 21 | at | Colorado Mines | 35 | | | |
| 9/22/2018 | Colorado Mines | 43 | at | New Mexico Highlands (4-7,4-6) | 14 | | | |
| 9/29/2018 | Colorado Mesa (7-4,6-4) | 31 | at | Colorado Mines | 72 | | | |
| 10/6/2018 | Colorado Mines | 44 | at | Western State (2-9,2-8) | 16 | | | |
| 10/13/2018 | Colorado Mines | 44 | at | Fort Lewis (1-9,1-9) | 14 | | | |
| 10/20/2018 | Azusa Pacific (8-4) | 27 | at | Colorado Mines | 42 | | | GNWAC |
| 10/27/2018 | South Dakota Tech (5-6,4-6) | 42 | at | Colorado Mines | 84 | | | |
| 11/3/2018 | Colorado Mines | 45 | at | Dixie State (7-4,7-3) | 52 | | | |
| 11/10/2018 | Chadron State (7-3,7-3) | 20 | at | Colorado Mines | 49 | | | |
| 11/17/2018 | Colorado State-Pueblo (11-2,10-1) | 37 | at | Colorado Mines | 17 | | D2 Playoff Round 1 | |