| 9/1/2018 | South Carolina State | 6 | at | Georgia Southern (10-3) | 37 | at SBC | ||
| 9/8/2018 | South Carolina State | 0 | at | UCF (12-1) | 38 | at AAC | ||
| 9/22/2018 | Norfolk State (4-7,3-5) | 17 | at | South Carolina State | 7 | |||
| 9/27/2018 | South Carolina State | 16 | at | North Carolina A&T (10-2,6-2) | 31 | |||
| 10/6/2018 | South Carolina State | 21 | at | Morgan State (4-7,4-4) | 18 | |||
| 10/13/2018 | Bethune-Cookman (7-5,5-2) | 28 | at | South Carolina State | 26 | |||
| 10/20/2018 | Delaware State (3-8,2-5) | 19 | at | South Carolina State | 30 | |||
| 10/27/2018 | South Carolina State | 27 | at | Howard (4-6,4-3) | 21 | |||
| 11/10/2018 | South Carolina State | 44 | at | Florida A&M (6-5,5-3) | 21 | |||
| 11/17/2018 | Savannah State (2-8,1-6) | 17 | at | South Carolina State | 21 | |||
| 11/24/2018 | North Carolina Central (5-6,3-4) | 21 | at | South Carolina State | 17 |
| vs South Carolina State | vs Other Opponents | South Carolina State compared to OOs | |
| Record: | 6-5 | 61-53 | |
| Points Scored: | 24.36 | 26.81 | 2.45 |
| Points Allowed: | 19.55 | 26.82 | -7.27 |
| Margin: | 4.81 | -0.01 | -4.82 |
| Total Points: | 43.91 | 53.63 | -9.72 |