| 8/25/2018 | Wyoming | 29 | at | New Mexico State (3-9) | 7 | at Ind | ||
| 9/1/2018 | Washington State (11-2) | 41 | at | Wyoming | 19 | P12 | ||
| 9/8/2018 | Wyoming | 13 | at | Missouri (8-5) | 40 | at SEC | ||
| 9/15/2018 | Wofford (9-4) | 14 | at | Wyoming | 17 | SoCon (1AA) | ||
| 9/29/2018 | Boise State (10-3,7-2) | 34 | at | Wyoming | 14 | |||
| 10/6/2018 | Wyoming | 13 | at | Hawaii (8-6,5-3) | 17 | |||
| 10/13/2018 | Wyoming | 3 | at | Fresno State (12-2,8-1) | 27 | |||
| 10/20/2018 | Utah State (11-2,7-1) | 24 | at | Wyoming | 16 | |||
| 10/26/2018 | Wyoming | 34 | at | Colorado State (3-9,2-6) | 21 | |||
| 11/3/2018 | San Jose State (1-11,1-7) | 9 | at | Wyoming | 24 | |||
| 11/17/2018 | Air Force (5-7,3-5) | 27 | at | Wyoming | 35 | |||
| 11/24/2018 | Wyoming | 31 | at | New Mexico (3-9,1-7) | 3 |
| vs Wyoming | vs Other Opponents | Wyoming compared to OOs | |
| Record: | 6-6 | 78-63 | |
| Points Scored: | 22.00 | 32.57 | 10.57 |
| Points Allowed: | 20.67 | 28.49 | -7.82 |
| Margin: | 1.33 | 4.08 | 2.75 |
| Total Points: | 42.67 | 61.06 | -18.39 |