| 8/31/2018 | Colorado State (3-9) | 13 | vs | Colorado | 45 | Denver CO | MW | |
| 9/8/2018 | Colorado | 33 | at | Nebraska (4-8) | 28 | at B10 | ||
| 9/15/2018 | New Hampshire (4-7) | 14 | at | Colorado | 45 | CAAF (1AA) | ||
| 9/28/2018 | UCLA (3-9,3-6) | 16 | at | Colorado | 38 | |||
| 10/6/2018 | Arizona State (7-6,5-4) | 21 | at | Colorado | 28 | |||
| 10/13/2018 | Colorado | 20 | at | Southern California (5-7,4-5) | 31 | |||
| 10/20/2018 | Colorado | 13 | at | Washington (10-4,8-2) | 27 | |||
| 10/27/2018 | Oregon State (2-10,1-8) | 41 | at | Colorado | 34 | OT | ||
| 11/2/2018 | Colorado | 34 | at | Arizona (5-7,4-5) | 42 | |||
| 11/10/2018 | Washington State (11-2,7-2) | 31 | at | Colorado | 7 | |||
| 11/17/2018 | Utah (9-5,6-4) | 30 | at | Colorado | 7 | |||
| 11/24/2018 | Colorado | 21 | at | California (7-6,4-5) | 33 |
| vs Colorado | vs Other Opponents | Colorado compared to OOs | |
| Record: | 7-5 | 63-75 | |
| Points Scored: | 27.25 | 26.95 | -0.30 |
| Points Allowed: | 27.08 | 27.64 | -0.56 |
| Margin: | 0.17 | -0.69 | -0.86 |
| Total Points: | 54.33 | 54.59 | -0.26 |