8/30/2018 | Frostburg State | 34 | at | Stevenson | 7 | | | NJAC |
| Rowan | 41 | at | Widener | 34 | 2OT | | NJAC |
8/31/2018 | New Jersey | 21 | at | Fairleigh Dickinson-Florham | 35 | | | NJAC |
| Albright | 14 | at | Salisbury | 48 | | | @ NJAC |
| Delaware Valley | 10 | at | Wesley | 34 | | | @ NJAC |
9/1/2018 | Gallaudet | 21 | at | Alvernia | 26 | | | ECFC |
| Lebanon Valley | 21 | at | Franklin & Marshall | 44 | | | @ Cen |
| Susquehanna | 38 | at | Lycoming | 7 | | | Cen |
| Merchant Marine | 30 | at | Misericordia | 9 | | | NEWMAC |
| King's | 0 | at | Moravian | 24 | | | @ Cen |
| Hartwick | 28 | at | Wilkes | 24 | | | E8 |
9/8/2018 | Mary Hardin-Baylor | 91 | at | Albright | 7 | | | ASWC |
| Stevenson | 35 | at | Bridgewater VA | 23 | | | @ ODC |
| Wilkes | 30 | at | Lebanon Valley | 27 | OT | | |
| Delaware Valley | 52 | at | UMass Dartmouth | 21 | | | @ MSCAC |
| Lycoming | 33 | at | Widener | 19 | | | |
| Fairleigh Dickinson-Florham | 31 | at | William Paterson | 17 | | | @ NJAC |
9/15/2018 | Stevenson | 50 | at | Albright | 21 | | | |
| Fairleigh Dickinson-Florham | 49 | at | Alvernia | 14 | | | |
| Wilkes | 10 | at | Delaware Valley | 21 | | | |
| Hartwick | 48 | at | King's | 65 | | | E8 |
| Lebanon Valley | 10 | at | Lycoming | 23 | | | |
| Widener | 35 | at | Misericordia | 36 | | | |
9/22/2018 | Alvernia | 10 | at | Delaware Valley | 41 | | | |
| Lycoming | 27 | at | Fairleigh Dickinson-Florham | 21 | | | |
| Stevenson | 38 | at | King's | 17 | | | |
| Albright | 0 | at | Widener | 69 | | | |
| Misericordia | 47 | at | Wilkes | 45 | | | |
9/29/2018 | Fairleigh Dickinson-Florham | 48 | at | Albright | 34 | | | |
| Wilkes | 34 | at | Alvernia | 14 | | | |
| Widener | 27 | at | Lebanon Valley | 21 | | | |
| King's | 29 | at | Lycoming | 14 | | | |
| Castleton State | 33 | at | Misericordia | 52 | | | ECFC |
| Delaware Valley | 31 | at | Stevenson | 20 | | | |
10/6/2018 | Widener | 41 | at | King's | 25 | | | |
| Alvernia | 33 | at | Misericordia | 45 | | | |
| Lebanon Valley | 7 | at | Stevenson | 36 | | | |
| Albright | 43 | at | Wilkes | 47 | | | |
10/12/2018 | Wilkes | 31 | at | Fairleigh Dickinson-Florham | 16 | | | |
10/13/2018 | King's | 51 | at | Alvernia | 7 | | | |
| Lycoming | 16 | at | Delaware Valley | 23 | | | |
| Misericordia | 25 | at | Lebanon Valley | 21 | | | |
| Stevenson | 20 | at | Widener | 6 | | | |
10/20/2018 | King's | 37 | at | Albright | 26 | | | |
| Delaware Valley | 52 | at | Lebanon Valley | 7 | | | |
| Alvernia | 0 | at | Lycoming | 52 | | | |
| Fairleigh Dickinson-Florham | 33 | at | Misericordia | 37 | | | |
| Wilkes | 21 | at | Stevenson | 33 | | | |
10/27/2018 | Albright | 14 | at | Delaware Valley | 49 | | | |
| Lebanon Valley | 23 | at | Fairleigh Dickinson-Florham | 24 | | | |
| Misericordia | 41 | at | King's | 23 | | | |
| Alvernia | 0 | at | Widener | 51 | | | |
| Lycoming | 7 | at | Wilkes | 14 | | | |
11/3/2018 | Misericordia | 39 | at | Albright | 29 | | | |
| Lebanon Valley | 55 | at | Alvernia | 7 | | | |
| Widener | 17 | at | Fairleigh Dickinson-Florham | 21 | | | |
| Delaware Valley | 49 | at | King's | 0 | | | |
| Stevenson | 33 | at | Lycoming | 32 | | | |
11/10/2018 | Albright | 24 | at | Lebanon Valley | 30 | | | |
| Lycoming | 21 | at | Misericordia | 14 | | | |
| Fairleigh Dickinson-Florham | 0 | at | Stevenson | 34 | | | |
| Alvernia | 27 | at | University of New England | 42 | | | @ CCF |
| Delaware Valley | 33 | at | Widener | 0 | | | |
| King's | 45 | at | Wilkes | 0 | | | |
11/17/2018 | Muhlenberg | 20 | at | Delaware Valley | 13 | | D3 Playooff Round 1 | Cen |
| Lycoming | 20 | at | Franklin & Marshall | 21 | | | @ Cen |
| Ursinus | 70 | at | Misericordia | 14 | | | Cen |
| Stevenson | 7 | at | Susquehanna | 17 | | | @ Cen |