| 8/31/2018 | Utica | 9 | at | St Lawrence | 6 | OT | E8 | |
| 9/1/2018 | Rensselaer | 40 | at | Allegheny | 19 | @ NCA | ||
| Hobart | 7 | at | Brockport State | 56 | @ E8 | |||
| Rochester | 10 | at | Case Western Reserve | 38 | @ TPAC | |||
| St Vincent | 14 | at | Ithaca | 38 | TPAC | |||
| Husson | 7 | at | Union NY | 30 | ECFC | |||
| 9/8/2018 | Union NY | 28 | at | Coast Guard | 10 | @ NEWMAC | ||
| Morrisville | 24 | at | Hobart | 62 | E8 | |||
| Brockport State | 13 | at | Ithaca | 7 | E8 | |||
| Carnegie Mellon | 31 | at | Rochester | 7 | TPAC | |||
| Worcester Polytechnic | 14 | at | Rensselaer | 25 | NEWMAC | |||
| Norwich | 7 | at | St Lawrence | 40 | NEWMAC | |||
| 9/15/2018 | Ithaca | 21 | at | Alfred | 13 | @ E8 | ||
| Rochester | 20 | at | Alfred State | 14 | @ ECFC | |||
| St Lawrence | 12 | at | Brockport State | 65 | @ E8 | |||
| Hobart | 56 | at | Shenandoah | 48 | @ ODC | |||
| Union NY | 45 | at | Springfield | 10 | @ NEWMAC | |||
| Rensselaer | 23 | at | Utica | 20 | 3OT | @ E8 | ||
| 9/21/2018 | St Lawrence | 26 | at | Morrisville | 34 | @ E8 | ||
| 9/22/2018 | Hobart | 24 | at | Endicott | 27 | @ CCF | ||
| Emory & Henry | 52 | at | Rochester | 17 | ODC | |||
| Buffalo State | 14 | at | Rensselaer | 44 | E8 | |||
| Ithaca | 21 | at | St John Fisher | 14 | @ E8 | |||
| Curry | 6 | at | Union NY | 49 | CCF | |||
| 9/29/2018 | Thomas More | 48 | at | St Lawrence | 12 | D3Ind | ||
| 10/6/2018 | Union NY | 28 | at | Hobart | 29 | |||
| Rensselaer | 10 | at | Ithaca | 9 | ||||
| St Lawrence | 38 | at | Rochester | 24 | ||||
| 10/13/2018 | Rochester | 7 | at | Hobart | 52 | |||
| Ithaca | 24 | at | Union NY | 0 | ||||
| 10/20/2018 | Rochester | 3 | at | Ithaca | 28 | |||
| Hobart | 24 | at | Rensselaer | 31 | ||||
| Union NY | 29 | at | St Lawrence | 7 | ||||
| 10/27/2018 | St Lawrence | 6 | at | Ithaca | 28 | |||
| Rensselaer | 42 | at | Rochester | 0 | ||||
| 11/3/2018 | Ithaca | 10 | at | Hobart | 3 | |||
| St Lawrence | 20 | at | Rensselaer | 27 | ||||
| Rochester | 14 | at | Union NY | 35 | ||||
| 11/10/2018 | Ithaca | 24 | at | Cortland | 21 | @ E8 | ||
| Alfred | 41 | at | Rochester | 13 | E8 | |||
| Union NY | 34 | at | Rensselaer | 10 | ||||
| Hobart | 42 | at | St Lawrence | 31 | ||||
| 11/17/2018 | Utica | 44 | vs | Ithaca | 42 | Ithaca NY | vs E8 | |
| Husson | 14 | at | Rensselaer | 38 | D3 Playooff Round 1 | ECFC | ||
| 11/24/2018 | Rensselaer | 21 | at | Brockport State | 13 | @ E8 | ||
| 12/1/2018 | Rensselaer | 14 | at | Johns Hopkins | 37 | D3 Playoff | @ Cen |