| 9/2/2017 | Guilford | 38 | at | Huntingdon AL (9-2) | 24 | at USASC | ||
| 9/9/2017 | Guilford | 56 | at | Methodist (2-8) | 17 | at USASC | ||
| 9/16/2017 | Guilford | 21 | at | Davidson (2-9) | 42 | at Pio | ||
| 9/30/2017 | Guilford | 21 | at | Jacksonville (7-4) | 56 | at Pio | ||
| 10/7/2017 | Hampden-Sydney (6-4,4-2) | 21 | at | Guilford | 18 | |||
| 10/14/2017 | Guilford | 26 | at | Washington and Lee (8-3,5-1) | 47 | |||
| 10/21/2017 | Shenandoah (6-4,3-3) | 20 | at | Guilford | 45 | |||
| 10/28/2017 | Guilford | 49 | at | Bridgewater VA (4-6,1-5) | 23 | |||
| 11/4/2017 | Randolph-Macon (7-3,4-2) | 38 | at | Guilford | 22 | |||
| 11/11/2017 | Emory & Henry (3-7,1-5) | 38 | at | Guilford | 42 |
| vs Guilford | vs Other Opponents | Guilford compared to OOs | |
| Record: | 5-5 | 49-45 | |
| Points Scored: | 32.60 | 30.24 | -2.36 |
| Points Allowed: | 33.80 | 30.38 | 3.42 |
| Margin: | -1.20 | -0.14 | 1.06 |
| Total Points: | 66.40 | 60.62 | 5.78 |