| 9/2/2017 | Baldwin-Wallace (6-4) | 42 | at | Defiance | 2 | OAC | ||
| 9/9/2017 | Defiance | 0 | at | Hope (8-2) | 38 | at MIAA | ||
| 9/16/2017 | Defiance | 12 | at | Franklin (8-3,8-0) | 42 | |||
| 9/23/2017 | Defiance | 14 | at | Rose-Hulman (8-2,7-1) | 37 | |||
| 9/30/2017 | Earlham (0-10,0-8) | 14 | at | Defiance | 34 | |||
| 10/7/2017 | Manchester (6-4,5-3) | 23 | at | Defiance | 21 | |||
| 10/14/2017 | Defiance | 45 | at | Anderson (1-9,1-7) | 0 | |||
| 10/28/2017 | Hanover (4-6,4-4) | 37 | at | Defiance | 29 | |||
| 11/4/2017 | Defiance | 10 | at | Mt St Joseph (6-4,5-3) | 56 | |||
| 11/11/2017 | Bluffton (4-6,4-4) | 33 | at | Defiance | 26 |
| vs Defiance | vs Other Opponents | Defiance compared to OOs | |
| Record: | 8-2 | 43-48 | |
| Points Scored: | 32.20 | 32.27 | 0.07 |
| Points Allowed: | 19.30 | 33.10 | -13.80 |
| Margin: | 12.90 | -0.83 | -13.73 |
| Total Points: | 51.50 | 65.37 | -13.87 |