| 8/31/2017 | Kennesaw St (12-2) | 23 | at | Samford | 28 | BigS | ||
| 9/7/2017 | West Alabama (10-3) | 41 | at | Samford | 49 | GSC (D2) | ||
| 9/16/2017 | Samford | 14 | at | Georgia (13-2) | 42 | at SEC | ||
| 9/23/2017 | Samford | 34 | at | Western Carolina (7-5,5-3) | 38 | |||
| 9/30/2017 | The Citadel (5-6,3-5) | 14 | at | Samford | 35 | |||
| 10/7/2017 | Samford | 26 | at | VMI (0-11,0-8) | 7 | |||
| 10/21/2017 | Samford | 24 | at | Wofford (10-3,8-1) | 21 | |||
| 10/28/2017 | Chattanooga (3-8,3-5) | 23 | at | Samford | 21 | |||
| 11/4/2017 | Samford | 20 | at | Mercer (5-6,4-4) | 3 | |||
| 11/11/2017 | East Tennessee St (4-7,2-6) | 7 | at | Samford | 42 | |||
| 11/18/2017 | Furman (8-5,6-3) | 20 | at | Samford | 26 | |||
| 11/25/2017 | Samford | 17 | at | Kennesaw St (12-2) | 28 | 1AA Playoff Round 1 | at BigS |
| vs Samford | vs Other Opponents | Samford compared to OOs | |
| Record: | 4-8 | 84-51 | |
| Points Scored: | 22.25 | 27.67 | 5.42 |
| Points Allowed: | 28.00 | 23.08 | 4.92 |
| Margin: | -5.75 | 4.59 | 10.34 |
| Total Points: | 50.25 | 50.75 | -0.50 |