| 8/26/2017 | Colgate (7-4) | 20 | at | Cal Poly | 14 | Pat | ||
| 9/2/2017 | Cal Poly | 13 | at | San Jose State (2-11) | 34 | at MW | ||
| 9/9/2017 | Cal Poly | 38 | at | Northern Iowa (8-5) | 45 | OT | at MVC | |
| 9/23/2017 | Northern Arizona (7-5,6-2) | 28 | at | Cal Poly | 10 | |||
| 9/30/2017 | Cal Poly | 34 | at | Idaho State (4-7,2-6) | 38 | |||
| 10/7/2017 | Cal Poly | 14 | at | Southern Utah (9-3,7-2) | 20 | |||
| 10/21/2017 | Weber State (11-3,9-1) | 17 | at | Cal Poly | 3 | |||
| 10/28/2017 | Cal Poly | 28 | at | UC Davis (5-6,4-5) | 31 | |||
| 11/4/2017 | Portland State (0-11,0-9) | 28 | at | Cal Poly | 35 | |||
| 11/11/2017 | Sacramento State (7-4,6-3) | 49 | at | Cal Poly | 14 | |||
| 11/18/2017 | Cal Poly | 0 | at | Northern Colorado (3-7,2-6) | 42 |
| vs Cal Poly | vs Other Opponents | Cal Poly compared to OOs | |
| Record: | 10-1 | 53-65 | |
| Points Scored: | 32.00 | 28.86 | -3.14 |
| Points Allowed: | 18.45 | 31.03 | -12.58 |
| Margin: | 13.55 | -2.17 | -15.72 |
| Total Points: | 50.45 | 59.89 | -9.44 |