| 8/27/2016 | Peru State | 39 | at | Central Methodist (2-9,2-9) | 14 | | | |
| 9/3/2016 | Evangel (4-7,4-7) | 10 | at | Peru State | 42 | | | |
| 9/10/2016 | Peru State | 30 | at | Avila (0-11,0-11) | 28 | | | |
| 9/17/2016 | Missouri Valley (9-3,9-2) | 21 | at | Peru State | 17 | | | |
| 9/24/2016 | Peru State | 21 | at | MidAmerica Nazarene (6-5,6-5) | 17 | | | |
| 10/1/2016 | Baker (14-1,11-0) | 42 | at | Peru State | 21 | | | |
| 10/15/2016 | Peru State | 9 | at | William Penn (7-4,7-4) | 13 | | | |
| 10/22/2016 | Grand View (9-3,9-2) | 31 | at | Peru State | 21 | | | |
| 10/29/2016 | Peru State | 16 | at | Graceland (5-6,5-6) | 38 | | | |
| 11/5/2016 | Culver-Stockton (1-10,1-10) | 21 | at | Peru State | 60 | | | |
| 11/12/2016 | Peru State | 25 | at | Benedictine KS (7-4,7-4) | 34 | | | |