| 9/2/2016 | Muhlenberg (9-2) | 29 | at | Wilkes | 22 | Cen | ||
| 9/10/2016 | Wilkes | 20 | at | Lebanon Valley (4-6,4-5) | 38 | |||
| 9/17/2016 | Misericordia (1-9,1-8) | 23 | at | Wilkes | 46 | |||
| 9/24/2016 | Wilkes | 23 | at | Widener (6-4,6-3) | 25 | |||
| 10/1/2016 | Fairleigh Dickinson-Florham (2-8,2-7) | 32 | at | Wilkes | 28 | |||
| 10/15/2016 | Wilkes | 10 | at | Delaware Valley (9-2,7-2) | 52 | |||
| 10/22/2016 | Albright (8-3,7-2) | 69 | at | Wilkes | 13 | |||
| 10/29/2016 | Lycoming (3-7,2-7) | 26 | at | Wilkes | 28 | |||
| 11/5/2016 | Wilkes | 38 | at | Stevenson (9-2,8-1) | 35 | |||
| 11/12/2016 | King's (5-5,5-4) | 42 | at | Wilkes | 14 |
| vs Wilkes | vs Other Opponents | Wilkes compared to OOs | |
| Record: | 7-3 | 49-45 | |
| Points Scored: | 37.10 | 26.81 | -10.29 |
| Points Allowed: | 24.20 | 25.24 | -1.04 |
| Margin: | 12.90 | 1.57 | -11.33 |
| Total Points: | 61.30 | 52.05 | 9.25 |