| 9/3/2016 | Hardin-Simmons (9-2) | 26 | at | Southwestern Texas | 3 | ASWC | ||
| 9/10/2016 | McMurry (4-5) | 17 | at | Southwestern Texas | 24 | ASWC | ||
| 9/17/2016 | Southwestern Texas | 23 | at | East Texas Baptist (7-3) | 33 | at ASWC | ||
| 9/24/2016 | Southwestern Texas | 22 | at | Wisconsin-River Falls (4-6) | 42 | at WIAC | ||
| 10/8/2016 | Austin (3-7,1-5) | 7 | at | Southwestern Texas | 37 | |||
| 10/15/2016 | Southwestern Texas | 48 | at | Trinity TX (5-5,3-3) | 0 | |||
| 10/22/2016 | Texas Lutheran (2-8,2-4) | 38 | at | Southwestern Texas | 42 | |||
| 10/29/2016 | Southwestern Texas | 35 | at | Austin (3-7,1-5) | 0 | |||
| 11/5/2016 | Trinity TX (5-5,3-3) | 7 | at | Southwestern Texas | 20 | |||
| 11/12/2016 | Southwestern Texas | 35 | at | Texas Lutheran (2-8,2-4) | 31 |
| vs Southwestern Texas | vs Other Opponents | Southwestern Texas compared to OOs | |
| Record: | 3-7 | 41-43 | |
| Points Scored: | 20.10 | 30.89 | 10.79 |
| Points Allowed: | 28.90 | 32.11 | -3.21 |
| Margin: | -8.80 | -1.22 | 7.58 |
| Total Points: | 49.00 | 63.00 | -14.00 |