| 9/3/2016 | Eureka (8-2) | 21 | at | Knox | 14 | UMWAC | ||
| 9/10/2016 | Knox | 32 | at | Beloit (3-7,3-7) | 42 | |||
| 9/17/2016 | St Norbert (7-3,7-1) | 50 | at | Knox | 3 | |||
| 9/24/2016 | Knox | 19 | at | Ripon (2-8,2-6) | 33 | |||
| 10/8/2016 | Knox | 37 | at | Grinnell (0-10,0-8) | 6 | |||
| 10/15/2016 | Illinois College (6-4,5-3) | 35 | at | Knox | 28 | |||
| 10/22/2016 | Knox | 24 | at | Cornell IA (5-5,4-4) | 28 | |||
| 10/29/2016 | Knox | 17 | at | Lake Forest (8-2,7-2) | 55 | |||
| 11/5/2016 | Lawrence (3-7,2-6) | 27 | at | Knox | 33 | |||
| 11/12/2016 | Monmouth IL (10-1,8-0) | 57 | at | Knox | 9 |
| vs Knox | vs Other Opponents | Knox compared to OOs | |
| Record: | 8-2 | 44-47 | |
| Points Scored: | 35.40 | 28.13 | -7.27 |
| Points Allowed: | 21.60 | 29.45 | -7.85 |
| Margin: | 13.80 | -1.32 | -15.12 |
| Total Points: | 57.00 | 57.58 | -0.58 |