| 8/26/2016 | Dakota State | 34 | at | Dakota Wesleyan | 30 | NSAA | ||
| 8/27/2016 | Waldorf | 19 | at | Briar Cliff | 23 | NSAA | ||
| Olivet Nazarene | 21 | at | Midland U. | 49 | MSFA | |||
| 9/3/2016 | Kansas Wesleyan | 27 | at | Briar Cliff | 21 | KCAC | ||
| St Mary KS | 7 | at | Concordia NE | 23 | KCAC | |||
| Tabor | 21 | at | Dakota Wesleyan | 35 | KCAC | |||
| Friends | 21 | at | Doane | 45 | KCAC | |||
| Dakota State | 42 | at | Dordt | 45 | NSAA | |||
| Bethany KS | 3 | at | Hastings | 42 | KCAC | |||
| Bethel KS | 0 | at | Midland U. | 26 | KCAC | |||
| Ottawa | 0 | at | Morningside | 62 | KCAC | |||
| Sterling | 28 | at | Northwestern IA | 21 | KCAC | |||
| 9/10/2016 | Northwestern IA | 13 | at | Dickinson State | 42 | @ NSAA | ||
| McPherson | 13 | at | Dordt | 27 | KCAC | |||
| Dakota Wesleyan | 55 | at | Jamestown | 17 | @ NSAA | |||
| Midland U. | 42 | at | North Park | 24 | @ CCIW (D3) | |||
| Concordia NE | 34 | at | Ottawa | 23 | @ KCAC | |||
| Briar Cliff | 0 | at | Presentation | 29 | @ NSAA | |||
| Hastings | 35 | at | Valley City State | 32 | @ NSAA | |||
| Doane | 23 | at | William Jewell | 12 | @ GLV (D2) | |||
| 9/17/2016 | Midland U. | 38 | at | Briar Cliff | 3 | |||
| Northwestern IA | 7 | at | Concordia NE | 9 | ||||
| Doane | 61 | at | Dakota Wesleyan | 34 | ||||
| Morningside | 87 | at | Dordt | 14 | ||||
| Jamestown | 34 | at | Hastings | 44 | NSAA | |||
| 9/24/2016 | Concordia NE | 7 | at | Doane | 27 | |||
| Dakota Wesleyan | 39 | at | Hastings | 20 | ||||
| Dordt | 33 | at | Midland U. | 41 | ||||
| Briar Cliff | 6 | at | Northwestern IA | 42 | ||||
| Morningside | 21 | at | Wisconsin-Whitewater | 35 | @ WIAC (D3) | |||
| 10/1/2016 | Dordt | 38 | at | Briar Cliff | 10 | |||
| Doane | 30 | at | Midland U. | 20 | ||||
| Concordia NE | 13 | at | Morningside | 55 | ||||
| Hastings | 16 | at | Northwestern IA | 48 | ||||
| 10/8/2016 | Briar Cliff | 0 | at | Concordia NE | 56 | |||
| Dakota Wesleyan | 42 | at | Dordt | 37 | ||||
| Midland U. | 36 | at | Hastings | 22 | ||||
| Doane | 7 | at | Morningside | 69 | ||||
| 10/15/2016 | Concordia NE | 30 | at | Dakota Wesleyan | 52 | |||
| Hastings | 19 | at | Doane | 27 | ||||
| Northwestern IA | 64 | at | Dordt | 16 | ||||
| Morningside | 34 | at | Midland U. | 17 | ||||
| 10/22/2016 | Midland U. | 14 | at | Concordia NE | 20 | |||
| Northwestern IA | 27 | at | Dakota Wesleyan | 44 | ||||
| Dordt | 44 | at | Hastings | 43 | ||||
| Briar Cliff | 0 | at | Morningside | 70 | ||||
| 10/28/2016 | Hastings | 35 | at | Briar Cliff | 6 | |||
| 10/29/2016 | Morningside | 39 | at | Dakota Wesleyan | 6 | |||
| Dordt | 21 | at | Doane | 59 | ||||
| Midland U. | 0 | at | Northwestern IA | 41 | ||||
| 11/5/2016 | Dakota Wesleyan | 54 | at | Briar Cliff | 24 | |||
| Concordia NE | 35 | at | Dordt | 28 | ||||
| Morningside | 62 | at | Hastings | 3 | ||||
| Doane | 24 | at | Northwestern IA | 12 | ||||
| 11/12/2016 | Hastings | 28 | at | Concordia NE | 31 | |||
| Briar Cliff | 0 | at | Doane | 62 | ||||
| Dakota Wesleyan | 42 | at | Midland U. | 31 | ||||
| Northwestern IA | 13 | at | Morningside | 14 | ||||
| Dordt | 59 | at | Trinity Bible | 24 | @ None (Unk?) | |||
| 11/19/2016 | Eastern Oregon | 34 | at | Doane | 28 | Front | ||
| Tabor | 17 | at | Morningside | 65 | KCAC | |||
| 11/26/2016 | Morningside | 35 | at | St Francis IN | 42 | @ MSFA |