| 9/3/2015 | Fort Hays State (8-4,8-3) | 30 | at | Central Oklahoma | 29 | | | |
| 9/12/2015 | Central Oklahoma | 16 | at | Missouri Western (5-6,5-6) | 26 | | | |
| 9/19/2015 | Emporia State (11-3,9-3) | 38 | at | Central Oklahoma | 28 | | | |
| 9/26/2015 | Central Oklahoma | 16 | at | Northwest Missouri State (15-0,12-0) | 23 | | | |
| 10/3/2015 | Nebraska-Kearney (0-11,0-11) | 24 | at | Central Oklahoma | 36 | | | |
| 10/10/2015 | Central Oklahoma | 55 | at | Missouri Southern (1-10,1-10) | 21 | | | |
| 10/17/2015 | Central Missouri (8-3,8-3) | 45 | at | Central Oklahoma | 42 | | | |
| 10/24/2015 | Central Oklahoma | 38 | at | Washburn (5-6,5-6) | 27 | | | |
| 10/31/2015 | Central Oklahoma | 48 | at | Northeastern State (3-8,3-8) | 17 | | | |
| 11/7/2015 | Lindenwood (4-7,4-7) | 20 | at | Central Oklahoma | 37 | | | |
| 11/14/2015 | Central Oklahoma | 49 | at | Pittsburg State (6-5,6-5) | 31 | | | |
| 12/5/2015 | Central Oklahoma | 38 | vs | Southwestern Oklahoma State (8-4) | 21 | | Texarkana AR | vs GAC |