| 9/3/2015 | Henderson State | 23 | at | Southeastern Oklahoma State (6-5,6-5) | 16 | | | |
| 9/10/2015 | East Central (6-5,6-5) | 35 | at | Henderson State | 28 | | | |
| 9/19/2015 | Henderson State | 25 | at | Northwestern Oklahoma State (3-8,3-8) | 17 | | | |
| 9/26/2015 | Southwestern Oklahoma State (8-4,8-3) | 0 | at | Henderson State | 33 | | | |
| 10/3/2015 | Arkansas Tech (9-3,8-3) | 7 | at | Henderson State | 17 | | | |
| 10/10/2015 | Henderson State | 22 | at | Harding (7-4,7-4) | 17 | | | |
| 10/17/2015 | Henderson State | 41 | at | Arkansas-Monticello (1-10,1-10) | 3 | | | |
| 10/24/2015 | Southern Arkansas (7-4,7-4) | 28 | at | Henderson State | 29 | | | |
| 10/31/2015 | Southern Nazarene (1-10,1-10) | 7 | at | Henderson State | 76 | | | |
| 11/7/2015 | Henderson State | 22 | at | Oklahoma Baptist (2-9,2-9) | 14 | | | |
| 11/14/2015 | Henderson State | 21 | at | Ouachita (7-4,7-4) | 17 | | | |
| 11/21/2015 | Sioux Falls (9-3) | 16 | at | Henderson State | 23 | | NCAA D2 Championship - First Round | NSIC |
| 11/28/2015 | Emporia State (11-3) | 29 | at | Henderson State | 3 | | NCAA D2 Championship - Second Round | MAIAA |