| 9/5/2015 | Northern State (6-5,6-5) | 6 | at | Upper Iowa | 17 | | | |
| 9/12/2015 | Upper Iowa | 34 | at | Mary (1-10,1-10) | 16 | | | |
| 9/19/2015 | Minnesota-Crookston (1-10,1-10) | 3 | at | Upper Iowa | 45 | | | |
| 9/26/2015 | Upper Iowa | 24 | at | Minnesota-Duluth (9-3,8-3) | 28 | | | |
| 10/3/2015 | Minnesota State-Mankato (10-2,10-1) | 38 | at | Upper Iowa | 10 | | | |
| 10/10/2015 | Concordia-St Paul (1-10,1-10) | 20 | at | Upper Iowa | 52 | | | |
| 10/17/2015 | Upper Iowa | 35 | at | Winona State (5-6,5-6) | 21 | | | |
| 10/24/2015 | Southwest Minnesota State (8-3,8-3) | 34 | at | Upper Iowa | 19 | | | |
| 10/31/2015 | Upper Iowa | 20 | at | Augustana SD (9-3,9-2) | 41 | | | |
| 11/7/2015 | Upper Iowa | 34 | at | Wayne State NE (4-7,4-7) | 31 | OT | | |
| 11/14/2015 | Sioux Falls (9-3,9-2) | 69 | at | Upper Iowa | 20 | | | |