| 9/5/2015 | Kentucky Christian (2-9) | 7 | at | Duquesne | 47 | MSC (NAIA) | ||
| 9/12/2015 | Duquesne | 26 | at | Bucknell (4-7) | 7 | at Pat | ||
| 9/19/2015 | Duquesne | 13 | at | Dayton (10-2) | 24 | at Pio | ||
| 9/26/2015 | Duquesne | 14 | at | Albany NY (3-8) | 17 | at CAAF | ||
| 10/3/2015 | Central Conn (4-7,3-3) | 10 | at | Duquesne | 27 | |||
| 10/10/2015 | Alderson-Broaddus (6-4) | 18 | at | Duquesne | 53 | D2Ind (D2) | ||
| 10/17/2015 | Duquesne | 17 | at | Bryant (5-6,3-3) | 38 | |||
| 10/24/2015 | Duquesne | 16 | at | Robert Morris (4-7,2-4) | 7 | |||
| 10/31/2015 | Wagner (1-10,1-5) | 17 | at | Duquesne | 35 | |||
| 11/7/2015 | Duquesne | 41 | at | Sacred Heart (6-5,3-3) | 14 | |||
| 11/21/2015 | St Francis PA (6-4,4-2) | 20 | at | Duquesne | 30 | |||
| 11/28/2015 | Duquesne | 49 | at | William & Mary (9-4) | 52 | FCS Playoff Round 1 | at CAAF |
| vs Duquesne | vs Other Opponents | Duquesne compared to OOs | |
| Record: | 4-8 | 56-65 | |
| Points Scored: | 19.25 | 21.76 | 2.51 |
| Points Allowed: | 30.67 | 25.30 | 5.37 |
| Margin: | -11.42 | -3.54 | 7.88 |
| Total Points: | 49.92 | 47.06 | 2.86 |