| 9/3/2015 | Notre Dame OH | 44 | at | Charleston WV (10-2,9-1) | 56 | | | |
| 9/12/2015 | Virginia-Wise (1-10,1-9) | 0 | at | Notre Dame OH | 42 | | | |
| 9/19/2015 | Notre Dame OH | 24 | at | Robert Morris (4-7) | 35 | | | at NE |
| 9/26/2015 | Notre Dame OH | 14 | at | Shepherd (13-1,10-0) | 43 | | | |
| 10/3/2015 | Glenville State (7-4,6-4) | 38 | at | Notre Dame OH | 30 | | | |
| 10/10/2015 | Notre Dame OH | 29 | at | West Virginia State (5-6,5-5) | 32 | | | |
| 10/17/2015 | Concord (5-5,5-5) | 21 | at | Notre Dame OH | 23 | | | |
| 10/22/2015 | Notre Dame OH | 59 | at | West Liberty (5-6,5-5) | 51 | | | |
| 10/31/2015 | Fairmont State (6-4,6-4) | 33 | at | Notre Dame OH | 24 | | | |
| 11/7/2015 | Notre Dame OH | 47 | at | Urbana (2-9,1-9) | 30 | | | |
| 11/14/2015 | West Virginia Wesleyan (2-8,2-8) | 20 | at | Notre Dame OH | 60 | | | |