| 8/29/2015 | Bethel TN | 48 | at | Missouri Baptist | 7 | MSC | ||
| Midland U. | 21 | at | Olivet Nazarene | 27 | GPAC | |||
| Marian IN | 45 | at | St Xavier | 13 | ||||
| Trinity International | 45 | at | Trinity Bible | 0 | @ None (Unk?) | |||
| 9/5/2015 | Saint Ambrose | 25 | at | Concordia MI | 21 | |||
| Siena Heights | 45 | at | Lindenwood-Belleville | 20 | ||||
| Wisconsin-Oshkosh | 21 | at | Robert Morris IL | 23 | WIAC (D3) | |||
| St Xavier | 34 | at | St Francis IL | 28 | ||||
| Olivet Nazarene | 16 | at | St Francis IN | 59 | ||||
| Anderson | 10 | at | Taylor | 51 | HCA (D3) | |||
| 9/12/2015 | Concordia MI | 42 | at | Anderson | 26 | @ HCA (D3) | ||
| St Xavier | 24 | at | Ave Maria | 21 | @ Sun | |||
| St Francis IL | 13 | at | Lincoln MO | 10 | @ GLV (D2) | |||
| Indianapolis | 22 | at | Marian IN | 28 | GLV (D2) | |||
| Lindenwood-Belleville | 24 | at | Olivet Nazarene | 23 | ||||
| Missouri Baptist | 35 | at | Siena Heights | 42 | ||||
| St Francis IN | 48 | at | Taylor | 42 | ||||
| Robert Morris IL | 28 | at | Valley City State | 14 | @ NSAA | |||
| Trinity International | 34 | at | Wisconsin Lutheran | 27 | @ NAC (D3) | |||
| 9/19/2015 | Marian IN | 21 | at | Robert Morris IL | 30 | |||
| Concordia MI | 28 | at | Siena Heights | 27 | ||||
| Lindenwood-Belleville | 26 | at | Saint Ambrose | 40 | ||||
| Missouri Baptist | 7 | at | St Francis IL | 45 | ||||
| Trinity International | 3 | at | St Francis IN | 45 | ||||
| Webber International | 34 | at | St Xavier | 37 | Sun | |||
| Butler | 41 | at | Taylor | 10 | Pio (1AA) | |||
| 9/26/2015 | St Francis IN | 74 | at | Lindenwood-Belleville | 13 | |||
| Missouri Baptist | 0 | at | Marian IN | 76 | ||||
| Taylor | 40 | at | Olivet Nazarene | 0 | ||||
| St Francis IL | 24 | at | Robert Morris IL | 14 | ||||
| Dakota State | 35 | at | Saint Ambrose | 39 | NSAA | |||
| Siena Heights | 31 | at | St Xavier | 38 | ||||
| Concordia MI | 21 | at | Trinity International | 17 | ||||
| 10/3/2015 | St Francis IL | 12 | at | Concordia MI | 3 | |||
| St Francis IN | 45 | at | Marian IN | 42 | ||||
| Taylor | 41 | at | Missouri Baptist | 13 | ||||
| Robert Morris IL | 28 | at | Olivet Nazarene | 14 | ||||
| Saint Ambrose | 41 | at | Trinity International | 13 | ||||
| 10/10/2015 | St Xavier | 14 | at | Concordia MI | 35 | |||
| Lindenwood-Belleville | 42 | at | Missouri Baptist | 21 | ||||
| St Francis IL | 25 | at | Saint Ambrose | 10 | ||||
| Siena Heights | 25 | at | St Francis IN | 49 | ||||
| Marian IN | 36 | at | Taylor | 23 | ||||
| Olivet Nazarene | 22 | at | Trinity International | 6 | ||||
| 10/17/2015 | Marian IN | 69 | at | Lindenwood-Belleville | 13 | |||
| Olivet Nazarene | 52 | at | Missouri Baptist | 45 | ||||
| Taylor | 63 | at | Siena Heights | 21 | ||||
| Truman State | 24 | at | St Francis IL | 20 | GLV (D2) | |||
| Concordia MI | 7 | at | St Francis IN | 48 | ||||
| Saint Ambrose | 10 | at | St Xavier | 27 | ||||
| Robert Morris IL | 41 | at | Trinity International | 12 | ||||
| 10/24/2015 | Siena Heights | 45 | at | Olivet Nazarene | 35 | |||
| St Francis IN | 38 | at | Robert Morris IL | 29 | ||||
| Missouri Baptist | 6 | at | Saint Ambrose | 30 | ||||
| Lindenwood-Belleville | 34 | at | St Francis IL | 35 | ||||
| Trinity International | 18 | at | St Xavier | 27 | ||||
| Concordia MI | 24 | at | Taylor | 35 | ||||
| 10/31/2015 | Marian IN | 44 | at | Concordia MI | 0 | |||
| Robert Morris IL | 16 | at | Lindenwood-Belleville | 20 | ||||
| Saint Ambrose | 20 | at | Siena Heights | 19 | ||||
| Trinity International | 7 | at | St Francis IL | 22 | ||||
| Olivet Nazarene | 23 | at | St Xavier | 34 | ||||
| 11/7/2015 | St Francis IL | 0 | at | Marian IN | 28 | |||
| Concordia MI | 24 | at | Missouri Baptist | 7 | ||||
| Saint Ambrose | 33 | at | Olivet Nazarene | 17 | ||||
| St Xavier | 14 | at | Robert Morris IL | 28 | ||||
| Trinity International | 20 | at | Siena Heights | 44 | ||||
| Lindenwood-Belleville | 27 | at | Taylor | 41 | ||||
| 11/14/2015 | Lindenwood-Belleville | 34 | at | Concordia MI | 31 | |||
| Siena Heights | 17 | at | Marian IN | 45 | ||||
| St Francis IN | 64 | at | Missouri Baptist | 6 | ||||
| Robert Morris IL | 7 | at | Saint Ambrose | 27 | ||||
| Olivet Nazarene | 0 | at | St Francis IL | 40 | ||||
| Taylor | 34 | at | Trinity International | 28 | ||||
| 11/21/2015 | Campbellsville | 7 | at | Marian IN | 44 | NAIA FCS First Round | MSC | |
| St Xavier | 69 | at | Morningside | 75 | 4OT | NAIA FCS First Round | @ GPAC | |
| Reinhardt | 26 | at | St Francis IN | 37 | NAIA FCS First Round | MSC | ||
| 11/28/2015 | Marian IN | 30 | at | Grand View | 3 | NAIA Quarterfinal | @ HAAC | |
| Montana Tech | 20 | at | St Francis IN | 42 | NAIA Quarterfinal | Front | ||
| 12/5/2015 | Marian IN | 45 | at | St Francis IN | 14 | NAIA Semifinal | ||
| 12/19/2015 | Marian IN | 31 | vs | Southern Oregon | 14 | NAIA Championship (Daytona FL) | vs Front |