| 9/1/2014 | Miami-Florida (6-7,3-5) | 13 | at | Louisville | 31 | |||
| 9/6/2014 | Murray State (3-9) | 21 | at | Louisville | 66 | OVC (1AA) | ||
| 9/13/2014 | Louisville | 21 | at | Virginia (5-7,3-5) | 23 | |||
| 9/20/2014 | Louisville | 34 | at | Florida Intl (4-8) | 3 | at CUSA | ||
| 9/27/2014 | Wake Forest (3-9,1-7) | 10 | at | Louisville | 20 | |||
| 10/3/2014 | Louisville | 28 | at | Syracuse (3-9,1-7) | 6 | |||
| 10/11/2014 | Louisville | 17 | at | Clemson (10-3,6-2) | 23 | |||
| 10/18/2014 | North Carolina State (8-5,3-5) | 18 | at | Louisville | 30 | |||
| 10/30/2014 | Florida State (13-1,9-0) | 42 | at | Louisville | 31 | |||
| 11/8/2014 | Louisville | 38 | at | Boston College (7-6,4-4) | 19 | |||
| 11/22/2014 | Louisville | 31 | at | Notre Dame (8-5) | 28 | at ND | ||
| 11/29/2014 | Kentucky (5-7) | 40 | at | Louisville | 44 | SEC | ||
| 12/30/2014 | Georgia (10-3) | 37 | vs | Louisville | 14 | Belk Bowl (Charlotte) | SEC |
| vs Louisville | vs Other Opponents | Louisville compared to OOs | |
| Record: | 4-9 | 81-70 | |
| Points Scored: | 21.77 | 29.30 | 7.53 |
| Points Allowed: | 31.15 | 25.45 | 5.70 |
| Margin: | -9.38 | 3.85 | 13.23 |
| Total Points: | 52.92 | 54.75 | -1.83 |