| 8/30/2013 | Western Michigan (1-11) | 13 | at | Michigan State | 26 | MAC | ||
| 9/7/2013 | South Florida (2-10) | 6 | at | Michigan State | 21 | AAC | ||
| 9/14/2013 | Youngstown State (8-4) | 17 | at | Michigan State | 55 | MVC (1AA) | ||
| 9/21/2013 | Michigan State | 13 | at | Notre Dame (9-4) | 17 | at ND | ||
| 10/5/2013 | Michigan State | 26 | at | Iowa (8-5,5-3) | 14 | |||
| 10/12/2013 | Indiana (5-7,3-5) | 28 | at | Michigan State | 42 | |||
| 10/19/2013 | Purdue (1-11,0-8) | 0 | at | Michigan State | 14 | |||
| 10/26/2013 | Michigan State | 42 | at | Illinois (4-8,1-7) | 3 | |||
| 11/2/2013 | Michigan (7-6,3-5) | 6 | at | Michigan State | 29 | |||
| 11/16/2013 | Michigan State | 41 | at | Nebraska (9-4,5-3) | 28 | |||
| 11/23/2013 | Michigan State | 30 | at | Northwestern (5-7,1-7) | 6 | |||
| 11/30/2013 | Minnesota (8-5,4-4) | 3 | at | Michigan State | 14 | |||
| 12/7/2013 | Ohio State (12-2,8-1) | 24 | vs | Michigan State | 34 | B1G Championship | ||
| 1/1/2014 | Stanford (11-3) | 20 | vs | Michigan State | 24 | Rose Bowl presented by VIZIO - Pasadena | P12 |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 1-13 | 89-74 | |
| Points Scored: | 13.21 | 29.57 | 16.36 |
| Points Allowed: | 29.36 | 26.93 | 2.43 |
| Margin: | -16.15 | 2.64 | 18.79 |
| Total Points: | 42.57 | 56.50 | -13.93 |