| 9/1/2013 | Ohio (7-6) | 7 | at | Louisville | 49 | MAC | ||
| 9/7/2013 | Eastern Kentucky (6-6) | 7 | at | Louisville | 44 | OVC (1AA) | ||
| 9/14/2013 | Louisville | 27 | at | Kentucky (2-10) | 13 | at SEC | ||
| 9/21/2013 | Florida Intl (1-11) | 0 | at | Louisville | 72 | CUSA | ||
| 10/5/2013 | Louisville | 30 | at | Temple (2-10,1-7) | 7 | |||
| 10/10/2013 | Rutgers (6-7,3-5) | 10 | at | Louisville | 24 | |||
| 10/18/2013 | UCF (12-1,8-0) | 38 | at | Louisville | 35 | |||
| 10/26/2013 | Louisville | 34 | at | South Florida (2-10,2-6) | 3 | |||
| 11/8/2013 | Louisville | 31 | at | Connecticut (3-9,3-5) | 10 | |||
| 11/16/2013 | Houston (8-5,5-3) | 13 | at | Louisville | 20 | |||
| 11/23/2013 | Memphis (3-9,1-7) | 17 | at | Louisville | 24 | |||
| 12/5/2013 | Louisville | 31 | at | Cincinnati (9-4,6-2) | 24 | OT | ||
| 12/28/2013 | Miami-Florida (9-4) | 9 | vs | Louisville | 36 | Russell Athletic - Orlando | ACC |
| vs Louisville | vs Other Opponents | Louisville compared to OOs | |
| Record: | 1-12 | 69-80 | |
| Points Scored: | 12.15 | 26.24 | 14.09 |
| Points Allowed: | 35.15 | 26.51 | 8.64 |
| Margin: | -23.00 | -0.27 | 22.73 |
| Total Points: | 47.30 | 52.75 | -5.45 |