| 9/1/2012 | Beloit (0-10) | 6 | at | Chicago | 20 | MidW | ||
| 9/8/2012 | Concordia IL (10-1) | 27 | at | Chicago | 26 | NAC | ||
| 9/15/2012 | Chicago | 0 | at | Elmhurst (10-2) | 33 | at CCIW | ||
| 9/22/2012 | Chicago | 28 | at | Oberlin (4-6) | 9 | at NCA | ||
| 10/6/2012 | Allegheny (5-5) | 0 | at | Chicago | 10 | NCA | ||
| 10/13/2012 | Chicago | 17 | at | Wittenberg (10-2) | 41 | at NCA | ||
| 10/20/2012 | Chicago | 23 | at | Hiram (0-10) | 7 | at NCA | ||
| 10/27/2012 | Case Western Reserve (6-4,2-1) | 28 | at | Chicago | 15 | |||
| 11/3/2012 | Chicago | 14 | at | Carnegie Mellon (6-5,1-2) | 31 | |||
| 11/10/2012 | Washington U (5-5,3-0) | 23 | at | Chicago | 7 |
| vs Chicago | vs Other Opponents | Chicago compared to OOs | |
| Record: | 6-4 | 50-46 | |
| Points Scored: | 20.50 | 23.67 | 3.17 |
| Points Allowed: | 16.00 | 24.07 | -8.07 |
| Margin: | 4.50 | -0.40 | -4.90 |
| Total Points: | 36.50 | 47.74 | -11.24 |