| 9/1/2012 | Gallaudet (7-3) | 0 | at | Otterbein | 15 | ECFC | ||
| 9/15/2012 | Otterbein | 54 | at | Wilmington (1-9,1-8) | 10 | |||
| 9/22/2012 | John Carroll (6-4,5-4) | 7 | at | Otterbein | 21 | |||
| 9/29/2012 | Otterbein | 38 | at | Baldwin-Wallace (7-3,6-3) | 17 | |||
| 10/6/2012 | Muskingum (3-7,3-6) | 13 | at | Otterbein | 23 | |||
| 10/13/2012 | Otterbein | 0 | at | Heidelberg (9-2,8-1) | 21 | |||
| 10/20/2012 | Mount Union (15-0,9-0) | 51 | at | Otterbein | 0 | |||
| 10/27/2012 | Otterbein | 23 | at | Capital (2-8,2-7) | 9 | |||
| 11/3/2012 | Otterbein | 40 | at | Marietta (0-10,0-9) | 20 | |||
| 11/10/2012 | Ohio Northern (4-6,4-5) | 13 | at | Otterbein | 24 |
| vs Otterbein | vs Other Opponents | Otterbein compared to OOs | |
| Record: | 2-8 | 52-44 | |
| Points Scored: | 16.10 | 29.19 | 13.09 |
| Points Allowed: | 23.80 | 25.07 | -1.27 |
| Margin: | -7.70 | 4.12 | 11.82 |
| Total Points: | 39.90 | 54.26 | -14.36 |