| 9/1/2012 | Eureka (4-6) | 62 | at | Knox | 55 | UMWAC | ||
| 9/8/2012 | Knox | 20 | at | St Norbert (8-3,8-1) | 31 | |||
| 9/15/2012 | Carroll WI (8-2,7-2) | 48 | at | Knox | 6 | |||
| 9/22/2012 | Knox | 13 | at | Lake Forest (7-3,7-2) | 34 | |||
| 9/29/2012 | Knox | 17 | at | Ripon (5-5,5-4) | 42 | |||
| 10/6/2012 | Beloit (0-10,0-9) | 33 | at | Knox | 35 | |||
| 10/13/2012 | Knox | 38 | at | Cornell IA (5-5,5-4) | 42 | |||
| 10/20/2012 | Illinois College (8-2,7-2) | 49 | at | Knox | 29 | |||
| 11/3/2012 | Lawrence (2-8,2-8) | 42 | at | Knox | 63 | |||
| 11/10/2012 | Knox | 35 | at | Monmouth IL (5-5,5-4) | 49 |
| vs Knox | vs Other Opponents | Knox compared to OOs | |
| Record: | 8-2 | 44-47 | |
| Points Scored: | 43.20 | 26.77 | -16.43 |
| Points Allowed: | 31.10 | 28.36 | 2.74 |
| Margin: | 12.10 | -1.59 | -13.69 |
| Total Points: | 74.30 | 55.13 | 19.17 |