| 9/1/2012 | Panhandle State (3-6) | 14 | at | Missouri S&T | 55 | D2Ind | ||
| 9/6/2012 | Missouri S&T | 27 | at | Arkansas Tech (5-6) | 19 | at GAC | ||
| 9/15/2012 | Missouri S&T | 31 | at | McKendree (3-7,3-5) | 0 | |||
| 9/22/2012 | Kentucky Wesleyan (2-9,0-8) | 23 | at | Missouri S&T | 47 | |||
| 9/29/2012 | Indianapolis (10-3,8-0) | 54 | at | Missouri S&T | 35 | |||
| 10/6/2012 | Missouri S&T | 27 | at | Central State (4-7,4-4) | 21 | |||
| 10/13/2012 | William Jewell (2-9,1-7) | 17 | at | Missouri S&T | 52 | |||
| 10/20/2012 | Missouri S&T | 64 | at | Quincy (3-8,3-5) | 6 | |||
| 10/27/2012 | Urbana (7-4,5-3) | 12 | at | Missouri S&T | 13 | |||
| 11/3/2012 | Missouri S&T | 41 | at | St Joseph's (6-5,5-3) | 22 | |||
| 11/10/2012 | Missouri S&T | 66 | at | South Dakota Tech (2-9) | 17 | at D2Ind |
| vs Missouri S&T | vs Other Opponents | Missouri S&T compared to OOs | |
| Record: | 1-10 | 46-63 | |
| Points Scored: | 18.64 | 26.21 | 7.57 |
| Points Allowed: | 41.64 | 31.49 | 10.15 |
| Margin: | -23.00 | -5.28 | 17.72 |
| Total Points: | 60.28 | 57.70 | 2.58 |