| 8/29/2012 | Southern Nazarene (1-9,0-6) | 21 | at | Henderson State | 63 | |||
| 9/8/2012 | Henderson State | 47 | at | McKendree (3-7) | 24 | at GLV | ||
| 9/15/2012 | Henderson State | 73 | at | Arkansas Tech (5-6,4-5) | 34 | |||
| 9/22/2012 | Southeastern Oklahoma State (4-6,3-6) | 20 | at | Henderson State | 56 | |||
| 9/29/2012 | Henderson State | 50 | at | Southwestern Oklahoma State (3-7,3-6) | 22 | |||
| 10/6/2012 | Arkansas-Monticello (0-10,0-9) | 0 | at | Henderson State | 71 | |||
| 10/13/2012 | Henderson State | 38 | at | Harding (9-2,8-1) | 10 | |||
| 10/20/2012 | East Central (6-5,6-4) | 20 | at | Henderson State | 49 | |||
| 10/27/2012 | Henderson State | 44 | at | Southern Arkansas (8-3,7-2) | 36 | |||
| 11/10/2012 | Oauchita (6-4,5-4) | 7 | at | Henderson State | 42 | |||
| 11/24/2012 | Missouri Western (12-2) | 45 | at | Henderson State | 21 | D2 Playoffs | MAIAA |
| vs Henderson State | vs Other Opponents | Henderson State compared to OOs | |
| Record: | 1-10 | 56-51 | |
| Points Scored: | 21.73 | 28.72 | 6.99 |
| Points Allowed: | 50.36 | 25.38 | 24.98 |
| Margin: | -28.63 | 3.34 | 31.97 |
| Total Points: | 72.09 | 54.10 | 17.99 |