| 9/1/2012 | San Diego (8-3) | 14 | at | Cal Poly | 41 | Pio | ||
| 9/15/2012 | Cal Poly | 24 | at | Wyoming (4-8) | 22 | at MW | ||
| 9/22/2012 | UC Davis (4-7,3-5) | 20 | at | Cal Poly | 28 | |||
| 9/29/2012 | Cal Poly | 35 | at | North Dakota (5-6,4-5) | 17 | |||
| 10/5/2012 | Cal Poly | 45 | vs | Weber State (2-9,2-6) | 23 | |||
| 10/13/2012 | Northern Colorado (5-6,4-5) | 28 | at | Cal Poly | 56 | |||
| 10/20/2012 | Portland State (3-8,2-7) | 25 | at | Cal Poly | 37 | |||
| 10/27/2012 | Cal Poly | 29 | at | Sacramento State (6-5,5-4) | 35 | |||
| 11/3/2012 | Cal Poly | 17 | at | Eastern Washington (11-3,8-1) | 34 | |||
| 11/10/2012 | Idaho State (1-10,0-8) | 14 | at | Cal Poly | 70 | |||
| 11/17/2012 | Cal Poly | 42 | at | Northern Arizona (8-3,6-2) | 34 | |||
| 12/1/2012 | Cal Poly | 16 | at | Sam Houston (11-4) | 18 | FCS Round 2 | at SLC |
| vs Cal Poly | vs Other Opponents | Cal Poly compared to OOs | |
| Record: | 3-9 | 65-63 | |
| Points Scored: | 23.67 | 30.32 | 6.65 |
| Points Allowed: | 36.67 | 29.59 | 7.08 |
| Margin: | -13.00 | 0.73 | 13.73 |
| Total Points: | 60.34 | 59.91 | 0.43 |