| 9/1/2012 | Appalachian State | 13 | at | East Carolina (8-5) | 35 | at CUSA | ||
| 9/8/2012 | Montana (5-6) | 27 | at | Appalachian State | 35 | BSky | ||
| 9/15/2012 | The Citadel (7-4,5-3) | 52 | at | Appalachian State | 28 | |||
| 9/22/2012 | Appalachian State | 34 | at | Chattanooga (6-5,5-3) | 17 | |||
| 9/29/2012 | Coastal Carolina (8-5) | 14 | at | Appalachian State | 55 | BigS | ||
| 10/6/2012 | Elon (3-8,1-7) | 23 | at | Appalachian State | 35 | |||
| 10/13/2012 | Appalachian State | 28 | at | Samford (7-4,5-3) | 25 | |||
| 10/20/2012 | Wofford (9-4,6-2) | 38 | at | Appalachian State | 28 | |||
| 10/27/2012 | Appalachian State | 38 | at | Western Carolina (1-10,0-8) | 27 | |||
| 11/3/2012 | Appalachian State | 31 | at | Georgia Southern (10-4,6-2) | 28 | |||
| 11/10/2012 | Furman (3-8,2-6) | 28 | at | Appalachian State | 33 | |||
| 12/1/2012 | Illinois State (9-4) | 38 | at | Appalachian State | 37 | OT | FCS Round 2 | MVC |
| vs Appalachian State | vs Other Opponents | Appalachian State compared to OOs | |
| Record: | 4-8 | 72-59 | |
| Points Scored: | 29.33 | 28.85 | -0.48 |
| Points Allowed: | 32.92 | 26.21 | 6.71 |
| Margin: | -3.59 | 2.64 | 6.23 |
| Total Points: | 62.25 | 55.06 | 7.19 |