| 8/30/2012 | McNeese State (7-4) | 27 | at | Middle Tenn State | 21 | SLC (1AA) | ||
| 9/8/2012 | Florida Atlantic (3-9,2-6) | 17 | at | Middle Tenn State | 31 | |||
| 9/15/2012 | Middle Tenn State | 48 | at | Memphis (4-8) | 30 | at CUSA | ||
| 9/29/2012 | Middle Tenn State | 49 | at | Georgia Tech (7-7) | 28 | at ACC | ||
| 10/6/2012 | UL Monroe (8-5,6-2) | 31 | at | Middle Tenn State | 17 | |||
| 10/13/2012 | Middle Tenn State | 34 | at | Florida Intl (3-9,2-6) | 30 | |||
| 10/20/2012 | Middle Tenn State | 3 | at | Mississippi State (8-5) | 45 | at SEC | ||
| 10/27/2012 | North Texas (4-8,3-5) | 21 | at | Middle Tenn State | 38 | |||
| 11/1/2012 | Middle Tenn State | 34 | at | Western Kentucky (7-6,4-4) | 29 | |||
| 11/17/2012 | Middle Tenn State | 20 | at | South Alabama (2-11,1-7) | 12 | |||
| 11/24/2012 | Troy (5-7,3-5) | 21 | at | Middle Tenn State | 24 | |||
| 12/1/2012 | Middle Tenn State | 0 | at | Arkansas State (10-3,7-1) | 45 |
| vs Middle Tenn State | vs Other Opponents | Middle Tenn State compared to OOs | |
| Record: | 4-8 | 64-74 | |
| Points Scored: | 28.00 | 27.76 | -0.24 |
| Points Allowed: | 26.58 | 27.80 | -1.22 |
| Margin: | 1.42 | -0.04 | -1.46 |
| Total Points: | 54.58 | 55.56 | -0.98 |