| 9/1/2012 | Buffalo | 23 | at | Georgia (12-2) | 45 | at SEC | ||
| 9/8/2012 | Morgan State (4-7) | 34 | at | Buffalo | 56 | MEAC (1AA) | ||
| 9/19/2012 | Kent State (11-3,8-1) | 23 | at | Buffalo | 7 | |||
| 9/29/2012 | Buffalo | 17 | at | Connecticut (5-7) | 24 | at BigE | ||
| 10/6/2012 | Buffalo | 31 | at | Ohio (9-4,4-4) | 38 | |||
| 10/13/2012 | Buffalo | 3 | at | Northern Illinois (12-2,9-0) | 45 | |||
| 10/20/2012 | Pittsburgh (6-7) | 20 | at | Buffalo | 6 | BigE | ||
| 10/27/2012 | Toledo (9-4,6-2) | 25 | at | Buffalo | 20 | |||
| 11/3/2012 | Miami-Ohio (4-8,3-5) | 24 | at | Buffalo | 27 | |||
| 11/10/2012 | Western Michigan (4-8,2-6) | 24 | at | Buffalo | 29 | |||
| 11/17/2012 | Buffalo | 29 | at | Massachusetts (1-11,1-7) | 19 | |||
| 11/23/2012 | Buffalo | 7 | vs | Bowling Green (8-5,6-2) | 21 | Columbus OH |
| vs Buffalo | vs Other Opponents | Buffalo compared to OOs | |
| Record: | 8-4 | 77-64 | |
| Points Scored: | 28.50 | 27.47 | -1.03 |
| Points Allowed: | 21.25 | 25.78 | -4.53 |
| Margin: | 7.25 | 1.69 | -5.56 |
| Total Points: | 49.75 | 53.25 | -3.50 |