| 8/27/2011 Grand View (NAIA) 48 at Black Hills State (D2) 14 |
| 8/27/2011 Jamestown (NAIA) 23 at South Dakota Tech (D2) 20 OT |
| 9/1/2011 Anderson (D3) 6 at Taylor (NAIA) 28 |
| 9/3/2011 Langston (NAIA) 19 vs Ark Pine Bluff (1AA) 12 |
| 9/3/2011 Indiana 20 vs Ball State 27 |
| 9/3/2011 Wisconsin-Eau Claire (D3) 21 at Bethel TN (NAIA) 26 |
| 9/3/2011 Walsh (D2) 14 at Cumberlands KY (NAIA) 31 |
| 9/3/2011 Richmond (1AA) 23 at Duke 21 |
| 9/3/2011 Boise State 35 vs Georgia 21 |
| 9/3/2011 Colorado 17 at Hawaii 34 |
| 9/3/2011 UCLA 34 at Houston 38 |
| 9/3/2011 BYU 14 at Mississippi 13 |
| 9/3/2011 Lindenwood (D2) 22 at Northern Colorado (1AA) 20 |
| 9/3/2011 Sacramento State (1AA) 29 at Oregon State 28 OT |
| 9/3/2011 Trinity Bible (NAIA) 36 at Presentation (D3) 28 |
| 9/3/2011 Albany State GA (D2) 37 vs Savannah State (1AA) 34 |
| 9/3/2011 Black Hills State (D2) 7 at Wisconsin-Stout (D3) 19 |
| 9/3/2011 Franklin (D3) 49 at Valparaiso (1AA) 35 |
| 9/9/2011 Florida Intl 24 at Louisville 17 |
| 9/10/2011 La Verne (D3) 14 at Azusa Pacific (NAIA) 65 |
| 9/10/2011 Mississippi College (D3) 31 at Belhaven (NAIA) 35 |
| 9/10/2011 Boston College 3 at UCF 30 |
| 9/10/2011 William Penn (NAIA) 24 at Luther (D3) 13 |
| 9/10/2011 New Mexico State 28 at Minnesota 21 |
| 9/10/2011 Coe (D3) 10 at Olivet Nazarene (NAIA) 16 OT |
| 9/10/2011 Menlo (NAIA) 23 at Pacific (D3) 16 |
| 9/10/2011 Kentucky Wesleyan (D2) 17 at Pikeville (NAIA) 24 |
| 9/10/2011 Purdue 22 at Rice 24 |
| 9/10/2011 Howard Payne (D3) 15 at Southwestern Assemblies of God (NAIA) 21 |
| 9/10/2011 McMurry (D3) 24 at Texas-San Antonio (1AA) 21 |
| 9/10/2011 Langston (NAIA) 33 at Tuskegee (D2) 19 |
| 9/17/2011 Northwestern 14 at Army 21 |
| 9/17/2011 Southwestern Assemblies of God (NAIA) 35 at Austin (D3) 13 |
| 9/17/2011 Whittier (D3) 3 at Azusa Pacific (NAIA) 51 |
| 9/17/2011 Mayville State (NAIA) 9 at Gustavus Adolphus (D3) 6 |
| 9/17/2011 Saint Ambrose (NAIA) 24 at Malone (D2) 22 |
| 9/17/2011 Notre Dame OH (D2) 0 at Marian IN (NAIA) 38 |
| 9/17/2011 Menlo (NAIA) 41 at Occidental (D3) 17 |
| 9/17/2011 Washington State 24 at San Diego State 42 |
| 9/17/2011 McKendree (D2) 7 at St Francis IN (NAIA) 33 |
| 9/17/2011 Walsh (D2) 30 at St Xavier (NAIA) 55 |
| 9/17/2011 Emory & Henry (D3) 30 at Virginia-Wise (NAIA) 33 |
| 9/17/2011 Indiana State (1AA) 44 at Western Kentucky 16 |
| 9/24/2011 Chapman (D3) 7 at Azusa Pacific (NAIA) 43 |
| 9/24/2011 Marian IN (NAIA) 56 at Malone (D2) 0 |
| 9/24/2011 Temple 38 at Maryland 7 |
| 9/24/2011 North Dakota State (1AA) 37 at Minnesota 24 |
| 9/24/2011 Sam Houston (1AA) 48 at New Mexico 45 OT |
| 9/24/2011 Indiana 21 at North Texas 24 |
| 9/24/2011 Valley City State (NAIA) 29 at South Dakota Tech (D2) 17 |
| 9/24/2011 Southern Utah (1AA) 41 at UNLV 16 |
| 9/24/2011 Southern Miss 30 at Virginia 24 |
| 9/24/2011 Menlo (NAIA) 24 at Whitworth (D3) 17 |
| 9/24/2011 McKendree (D2) 0 at William Penn (NAIA) 21 |
| 10/1/2011 Wesley (D3) 32 at Charleston Southern (1AA) 20 |
| 10/1/2011 Western Michigan 38 at Connecticut 31 |
| 10/1/2011 Marshall 17 at Louisville 13 |
| 10/1/2011 Walsh (D2) 13 at Marian IN (NAIA) 20 |
| 10/1/2011 Missouri S&T (D2) 17 at Northwestern Oklahoma State (NAIA) 22 |
| 10/8/2011 Livingstone (D2) 13 at Edward Waters (NAIA) 14 |
| 10/8/2011 Southern Virginia (NAIA) 55 at Guilford (D3) 24 |
| 10/8/2011 Panhandle State (D2) 23 at Langston (NAIA) 41 |
| 10/8/2011 St Xavier (NAIA) 52 at Malone (D2) 10 |
| 10/8/2011 McKendree (D2) 7 at Saint Ambrose (NAIA) 28 |
| 10/8/2011 Humboldt State (D2) 23 at UC Davis (1AA) 17 |
| 10/8/2011 St Francis IN (NAIA) 42 at Walsh (D2) 41 2 OT |
| 10/15/2011 Azusa Pacific (NAIA) 48 at Dixie State (D2) 19 |
| 10/15/2011 McKendree (D2) 0 at Grand View (NAIA) 14 |
| 10/15/2011 BYU 38 at Oregon State 28 |
| 10/20/2011 Lincoln PA (D2) 2 at unknown () 18 |
| 10/22/2011 Simon Fraser (D2) 28 at Southern Oregon (NAIA) 31 |
| 10/22/2011 Malone (D2) 10 at St Francis IN (NAIA) 47 |
| 10/22/2011 Wesley (D3) 28 at Walsh (D2) 3 |
| 10/29/2011 Southern Nazarene (NAIA) 28 at Panhandle State (D2) 7 |
| 11/5/2011 South Dakota Tech (D2) 0 at Dickinson State (NAIA) 17 |
| 11/5/2011 St Francis IL (NAIA) 30 at Georgia State (1AA) 27 OT |
| 11/5/2011 Quincy (NAIA) 38 at Malone (D2) 35 |
| 11/12/2011 Panhandle State (D2) 20 at Bacone (NAIA) 30 |
| 11/12/2011 Taylor (NAIA) 27 at Malone (D2) 13 |
| 11/12/2011 Louisiana Tech 27 at Mississippi 7 |
| 11/12/2011 McKendree (D2) 13 at Olivet Nazarene (NAIA) 17 |
| 11/12/2011 Central State (D2) 20 at St Francis IN (NAIA) 59 |
| 11/12/2011 Concordia AL (NAIA) 12 at Stillman (D2) 7 |
| 11/12/2011 Apprentice (D3) 6 at Webber International (NAIA) 51 |
| 11/12/2011 Georgia State (1AA) 23 at West Alabama (D2) 30 |
| 11/19/2011 Greenville (D3) 7 at Campbellsville (NAIA) 21 |