| 9/3/2011 | DePauw 23 @ Rose-Hulman Engineers 13 | |
| 9/17/2011 | DePauw 10 @ Allegheny Gators 17 | † |
| 9/24/2011 | DePauw 14 @ Rhodes Lynx 24 | |
| 10/1/2011 | Centre Praying Colonels 24 @ DePauw 10 | |
| 10/15/2011 | DePauw 7 @ Sewanee Tigers 30 | |
| 10/22/2011 | DePauw 34 @ Ohio Wesleyan Battling Bishops 10 | † |
| 10/29/2011 | DePauw 21 @ Austin Kangaroos 17 | |
| 11/5/2011 | Albion Britons 3 @ DePauw 7 | |
| 11/12/2011 | Wabash Little Giants 45 @ DePauw 7 | † |