| 9/3/2011 | Missouri S&T 34 @ Panhandle State Aggies 23 | |
| 9/10/2011 | Midwestern State Mustangs 41 @ Missouri S&T 0 | |
| 9/17/2011 | Missouri S&T 23 @ Drake Bulldogs 27 | |
| 9/24/2011 | Lindenwood Lions 13 @ Missouri S&T 19 | |
| 10/1/2011 | Missouri S&T 17 @ Northwestern Oklahoma State Rangers 22 | |
| 10/8/2011 | South Dakota Tech Jackrabbits 0 @ Missouri S&T 60 | |
| 10/15/2011 | Missouri S&T 52 @ Kentucky Wesleyan Panthers 28 | † |
| 10/22/2011 | William Jewell Cardinals 26 @ Missouri S&T 28 | |
| 10/29/2011 | Missouri S&T 7 @ Urbana Blue Knights 42 | † |
| 11/5/2011 | St Joseph's Pumas 24 @ Missouri S&T 45 | † |
| 11/12/2011 | Missouri S&T 14 @ South Dakota Coyotes 48 |