| 8/28/2010 | Langston Lions 28 @ Incarnate Word 20 | |
| 9/11/2010 | Incarnate Word 19 @ Southeastern Oklahoma State Savage Storm 38 | † |
| 9/18/2010 | Central Oklahoma Bronchos 41 @ Incarnate Word 42 | † |
| 9/25/2010 | Texas A&M-Kingsville Javelinas 37 @ Incarnate Word 9 | † |
| 10/2/2010 | Incarnate Word 31 @ Midwestern State Mustangs 38 | † |
| 10/9/2010 | Incarnate Word 27 @ East Central Tigers 13 | † |
| 10/16/2010 | Abilene Christian Wildcats 54 @ Incarnate Word 17 | † |
| 10/23/2010 | Incarnate Word 17 @ Angelo State Rams 61 | † |
| 10/30/2010 | West Texas A&M Buffaloes 49 @ Incarnate Word 10 | † |
| 11/6/2010 | Incarnate Word 27 @ Tarleton State Texans 41 | † |
| 11/13/2010 | Texas A&M-Commerce Lions 16 @ Incarnate Word 17 | † |