| 9/4/2010 | Northwestern MN 10 @ St John's MN Johnnies 56 | |
| 9/11/2010 | Luther Norse 31 @ Northwestern MN 7 | |
| 9/18/2010 | Northwestern MN 0 @ Gustavus Adolphus Golden Gusties 29 | |
| 10/2/2010 | MacMurray Highlanders 34 @ Northwestern MN 37 | † |
| 10/9/2010 | Northwestern MN 24 @ Crown Storm 30 | † |
| 10/16/2010 | Minnesota-Morris Cougars 35 @ Northwestern MN 33 | † |
| 10/23/2010 | Northwestern MN 14 @ Eureka Red Devils 40 | † |
| 10/30/2010 | Westminster MO Blue Jays 27 vs Northwestern MN 9 (Minneapolis MN) | † |
| 11/6/2010 | Northwestern MN 7 @ St Scholastica Saints 10 | † |
| 11/13/2010 | Martin Luther Knights 35 @ Northwestern MN 33 | † |