| 9/4/2010 | Dakota Wesleyan 42 @ Dordt Defenders 7 | † |
| 9/11/2010 | Concordia NE Bulldogs 0 @ Dakota Wesleyan 56 | † |
| 9/25/2010 | Dakota Wesleyan 37 @ Doane Tigers 3 | † |
| 10/2/2010 | Midland Lutheran Warriors 21 @ Dakota Wesleyan 19 | † |
| 10/9/2010 | Dakota Wesleyan 20 @ Nebraska Wesleyan Prairie Wolves 27 | † |
| 10/16/2010 | Hastings Broncos 21 @ Dakota Wesleyan 34 | † |
| 10/23/2010 | Dakota Wesleyan 3 @ Sioux Falls Cougars 63 | † |
| 10/30/2010 | Dakota Wesleyan 10 @ Northwestern IA Red Raiders 16 | † |
| 11/6/2010 | Briar Cliff Chargers 14 @ Dakota Wesleyan 49 | † |
| 11/13/2010 | Morningside Mustangs 45 @ Dakota Wesleyan 8 | † |