| 9/4/2010 | Austin Kangaroos 28 @ Southwestern Assemblies of God 6 | |
| 9/11/2010 | Southwestern Assemblies of God 7 @ Howard Payne Yellow Jackets 32 | |
| 9/18/2010 | Trinity Bible Lions 24 @ Southwestern Assemblies of God 38 | |
| 10/2/2010 | Southwestern Assemblies of God 21 @ Southern Nazarene Crimson Storm 35 | † |
| 10/9/2010 | Southwestern Assemblies of God 17 @ Bacone Warriors 66 | † |
| 10/16/2010 | Southwestern Assemblies of God 27 @ Langston Lions 41 | † |
| 10/23/2010 | Southwestern Assemblies of God 31 @ Panhandle State Aggies 35 | |
| 10/30/2010 | Northwestern Oklahoma State Rangers 44 @ Southwestern Assemblies of God 7 | † |
| 11/6/2010 | Haskell Indians 15 @ Southwestern Assemblies of God 29 | |
| 11/13/2010 | Texas College Steers @ Southwestern Assemblies of God | † |