| 9/4/2010 | Mississippi College Choctaws 27 @ Millsaps 23 | |
| 9/11/2010 | Millsaps 21 @ LaGrange Panthers 27 | |
| 9/18/2010 | Austin Kangaroos 24 @ Millsaps 38 | † |
| 9/25/2010 | Millsaps 27 @ Trinity TX Tigers 23 | † |
| 10/2/2010 | DePauw Tigers 35 @ Millsaps 21 | † |
| 10/9/2010 | Huntingdon AL Hawks 19 @ Millsaps 35 | |
| 10/16/2010 | Millsaps 70 @ Rhodes Lynx 31 | † |
| 10/23/2010 | Millsaps 30 @ Centre Praying Colonels 18 | † |
| 10/30/2010 | Sewanee Tigers 0 @ Millsaps 30 | † |
| 11/13/2010 | Millsaps 28 @ Birmingham-Southern Panthers 17 | † |