| 9/25/2010 | Bowdoin Polar Bears 15 @ Williams 33 | † |
| 10/2/2010 | Trinity CT Bantams 21 @ Williams 29 | † |
| 10/9/2010 | Williams 41 @ Bates Bobcats 0 | † |
| 10/16/2010 | Middlebury Panthers 17 @ Williams 41 | † |
| 10/23/2010 | Williams 35 @ Tufts Jumbos 24 | † |
| 10/30/2010 | Williams 38 @ Hamilton Continentals 7 | † |
| 11/6/2010 | Wesleyan Cardinals 7 @ Williams 45 | † |
| 11/13/2010 | Williams 31 @ Amherst Lord Jeffs 16 | † |