| 9/4/2010 | Carroll WI Pioneers 35 @ Lakeland 21 | |
| 9/11/2010 | Carthage Red Men 35 @ Lakeland 34 | |
| 9/25/2010 | Lakeland 27 @ Hope Flying Dutchmen 12 | |
| 10/2/2010 | Lakeland 7 @ Aurora Spartans 23 | † |
| 10/9/2010 | Rockford Regents 0 @ Lakeland 42 | † |
| 10/16/2010 | Lakeland 9 @ Wisconsin Lutheran Warriors 20 | † |
| 10/23/2010 | Lakeland 7 @ Concordia IL Cougars 48 | † |
| 10/30/2010 | Ill. Benedictine Eagles 46 @ Lakeland 21 | † |
| 11/6/2010 | Lakeland 42 @ Maranatha Baptist Bible Crusaders 0 | † |
| 11/13/2010 | Concordia WI Falcons 7 @ Lakeland 29 | † |