| 8/28/2010 | Winona State Warriors 24 @ Carson-Newman 21 | |
| 9/2/2010 | Bentley Falcons 28 @ Carson-Newman 35 | |
| 9/16/2010 | Concordia AL Hornets 7 @ Carson-Newman 37 | |
| 9/25/2010 | Carson-Newman 7 @ UNC Pembroke Braves 30 | |
| 10/2/2010 | Carson-Newman 35 @ Brevard Tornados 17 | † |
| 10/9/2010 | Wingate Bulldogs 38 @ Carson-Newman 35 | † |
| 10/16/2010 | Carson-Newman 42 @ Catawba Indians 16 | † |
| 10/21/2010 | Mars Hill Lions 27 @ Carson-Newman 34 | † |
| 10/30/2010 | Carson-Newman 35 @ Newberry Wolves 13 | † |
| 11/6/2010 | Lenoir-Rhyne Bears 52 @ Carson-Newman 14 | † |
| 11/13/2010 | Carson-Newman 49 @ Tusculum Pioneers 48 | † |