| 8/26/2010 | Emporia State Hornets 27 @ Southwestern Oklahoma State 7 | |
| 9/11/2010 | West Texas A&M Buffaloes 77 @ Southwestern Oklahoma State 14 | † |
| 9/18/2010 | Southwestern Oklahoma State 9 @ Midwestern State Mustangs 46 | † |
| 9/25/2010 | Southwestern Oklahoma State 0 @ East Central Tigers 23 | † |
| 10/2/2010 | Eastern New Mexico Greyhounds 10 @ Southwestern Oklahoma State 21 | † |
| 10/9/2010 | Southwestern Oklahoma State 35 @ Southeastern Oklahoma State Savage Storm 42 | † |
| 10/16/2010 | Northeastern State Riverhawks 20 @ Southwestern Oklahoma State 10 | † |
| 10/24/2010 | Southwestern Oklahoma State 24 @ Texas A&M-Commerce Lions 10 | † |
| 10/30/2010 | Texas A&M-Kingsville Javelinas 56 @ Southwestern Oklahoma State 17 | † |
| 11/6/2010 | Central Oklahoma Bronchos 24 @ Southwestern Oklahoma State 31 | † |
| 11/13/2010 | Southwestern Oklahoma State 17 @ Abilene Christian Wildcats 47 | † |